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In vitro miR‐125a regulates Smurf1 expression by binding to the 3′‐UTR of Smurf1. (A) Schematic representation of the Smurf1 3′‐UTR as a direct target for miR‐125a. (B) WT or Mut miR‐125a target sssss of the Smurf1 3′‐UTR. (C) Luciferase activity of cells cotransfected with the WT or Mut CDKN1A 3′‐UTR reporter genes or negative control miRNA mimics (pMIR‐reporter). Three experiment replicates were performed. Data are presented as mean ± SD. One‐way ANOVA. ** P < 0.01.
