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. 2019 Jun 4;9(7):1223–1231. doi: 10.1002/2211-5463.12651

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© 2019 The Authors. Published by FEBS Press and John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Down‐regulation of TCTN2 in SCI rat model and OGD‐induced neurons and its influence on neuronal apoptosis. SCI rat model (SCI, n = 6) was constructed, and the rats in sham group (n = 6) served as control. (A) Neurological function of rats was assessed with BBB scoring at 1, 6, 12, 24, and 48 h after SCI establishment. (B) Forty‐eight hours following SCI, the spinal tissue of mice was taken and the expression of TCTN2 and miR‐216b in spinal tissue was quantified with qRT‐PCR. (C) The protein expression of Beclin‐1 was determined with western blot 48 h after SCI. *P < 0.05 compared with the sham group. The error bars indicated SD. The experiments were repeated three times. Comparisons between the two groups were analyzed with Student's t test.