Table 2.
Fatty acid profiles in plasma of control (C) and in utero exposed (E) F1 adult pregnant dams at 28dpc (% of total fatty acids).
| Variable | Number of dams | Median [Q1; Q3] | Fully adjusted linear model | ||||
|---|---|---|---|---|---|---|---|
| C | E | Control | Exposed | β value | CI | p-value | |
| C16:0 (PA) | 3 | 9 | 29.1 [28.5; 30.1] | 31.8 [30.4; 32.8] | 2.55 | [0.53; 4.57] | 0.067 |
| C16:1n-7 | 3 | 9 | 10.4 [8.2; 11.5] | 6.4 [6.1; 8.2] | −3.15 | [−4.98; −1.31] | 0.027* |
| Total C16:1 | 3 | 9 | 10.9 [8.6; 11.9] | 7.1 [6.6; 8.6] | −3.10 | [−4.91; −1.28] | 0.028* |
| C18:0 (SA) | 3 | 9 | 8.0 [6.0; 9.2] | 10.0 [8.7; 12.7] | 3.73 | [−0.90; 8.36] | 0.186 |
| Total C18:1 | 3 | 9 | 25.2 [25.0; 28.8] | 25.4 [24.2; 29.5] | −1.03 | [−8.21; 6.15] | 0.791 |
| C18:2 n-6 (LA) | 3 | 9 | 17.7 [16.9; 17.9] | 16.2 [15.4; 17.3] | −1.25 | [−2.44; −0.06] | 0.106 |
| C18:3 n-3 (ALA) | 3 | 9 | 2.8 [2.5; 3.3] | 1.8 [1. 6; 2.0] | −1.22 | [−1.85; −0.59] | 0.019* |
| C20:4 n-6 (AA) | 3 | 9 | 1.5 [0.9; 1.6] | 1.0 [0.8; 1.7] | −0.06 | [−0.84; 0.72] | 0.892 |
| C20:5 n-3 (EPA) | 3 | 9 | 0.02 [0.00; 0.04] | 0.04 [0.02; 0.37] | 0.18 | [−0.34; 0.71] | 0.529 |
| C22:4 n-6 | 3 | 9 | 0.04 [0.04; 0.11] | 0.04 [0.03; 0.06] | −0.01 | [−0.08; 0.06] | 0.794 |
| C22:5 n-6 | 3 | 9 | 0.08 [0.00; 0.08] | 0.06 [0.05; 0.11] | 0.04 | [−0.05; 0.14] | 0.397 |
| C22:5 n-3 (DPA) | 3 | 9 | 0.07 [0.05; 0.08] | 0.05 [0.02; 0.08] | −0.01 | [−0.07; 0.05] | 0.710 |
| C22:6 n-3 (DHA) | 3 | 9 | 0.05 [0.04; 0.07] | 0.04 [0.03; 0.06] | −0.01 | [−0.05; 0.03] | 0.608 |
| Total SFA | 3 | 9 | 39.9 [38.7; 40.0] | 44.9 [41.5; 47.5] | 6.37 | [−0.98; 13.71] | 0.162 |
| Total MUFA | 3 | 9 | 37.8 [36.7; 37.9] | 34.6 [31.4; 37.3] | −4.04 | [−10.34; 2.25] | 0.272 |
| Total n-6 PUFA | 3 | 9 | 19.7 [19.4; 20.1] | 18.9 [17.6; 19.3] | −1.16 | [−3.05; 0.72] | 0.289 |
| Total n-3 PUFA | 3 | 9 | 3.2 [2.9; 3.7] | 2.3 [2.1; 2.8] | −1.11 | [−2.01; −0.22] | 0.068 |
| n-6/n-3 PUFA ratio | 3 | 9 | 6.4 [5.3; 6.8] | 8.2 [6.6; 9.5] | 2.64 | [−0.59; 5.88] | 0.181 |
| PUFA/SFA ratio | 3 | 9 | 0.58 [0.56; 0.60] | 0.50 [0.42; 0.52] | −0.11 | [−0.19; −0.03] | 0.049* |
| DNL index | 3 | 9 | 1.7 [1.6; 1.7] | 1.9 [1.8; 2.1] | 0.30 | [0.06; 0.53] | 0.070 |
Data are expressed as Median[Q1;Q3], in % of total FA. AA: C20:4n-6, arachidonic acid; ALA: C18:3n-3, alpha-linolenic acid; CI: Confidence Interval; DHA: C22:6n-3, docosahexaenoic acid; DNL index: de novo lipogenesis (C16:0/C18:2n-6 ratio)22,23; DPA: C22:5n-3, docosapentaenoic acid; EPA: C20:5n-3, Eicosapentaenoic acid; LA: C18:2n-6, linoleic acid; MUFA: monounsaturated fatty acids; PA: C16:0, palmitic acid; PL: phospholipids; PUFA: polyunsaturated fatty acids; SA: C18:0, stearic acid; SFA: saturated fatty acids “Statistics with *P < 0.05” and **P < 0.01.