Table 3.
Profile in fatty acid in F2 of control (CC) and exposed (EC) placenta phospholipids (PL) at 28 dpc (% of total fatty acids).
| Variable | Number of placenta | Median [Q1; Q3] | Fully adjusted linear model | ||||
|---|---|---|---|---|---|---|---|
| CC | EC | CC | EC | β value | CI | p-value | |
| C15:0 | 12 | 12 | 0.52 [0.51; 0.56] | 0.45 [0.42; 0.49] | −0.09 | [−0.148; −0.027] | 0.025* |
| C16:0 (PA) | 12 | 12 | 29.3 [28.9; 30.0] | 29.1 [28.9; 29.4] | −0.50 | [−1.514; 0.51] | 0.359 |
| C16:1n-9 | 12 | 12 | 4.0 [3.6; 4.6] | 4.9 [4.5; 5.0] | 0.68 | [0.234; 1.131] | 0.020* |
| Total C16:1 | 12 | 12 | 6.1 [5.5; 6.7] | 7.0 [6.7; 7.2] | 0.83 | [0.35; 1.307] | 0.011* |
| C18:0 (SA) | 12 | 12 | 17.3 [17.0; 17.6] | 17.0 [16.5; 17.3] | −0.32 | [−0.728; 0.083] | 0.160 |
| Total C18:1 | 12 | 12 | 19.3 [18.9; 19.7] | 19.4 [18.8; 20.2] | 0.38 | [−0.663; 1.414] | 0.497 |
| C18:2 n-6 (LA) | 12 | 12 | 11.8 [10.9; 12.1] | 12.4 [11.8; 13.0] | 0.63 | [−0.051; 1.304] | 0.110 |
| C18:3n-6 (GLA) | 12 | 12 | 0.58 [0.50; 0.69] | 0.79 [0.75; 0.87] | 0.20 | [0.065; 0.328] | 0.021* |
| C18:3n-3 (ALA) | 12 | 12 | 0.09 [0.07; 0.09] | 0.08 [0.07; 0.08] | −0.01 | [−0.016; 0.002] | 0.190 |
| C20:2n-6 | 12 | 12 | 0.16 [0.14; 0.17] | 0.13 [0.12; 0.14] | −0.03 | [−0.048; −0.011] | 0.017* |
| C20:3n-6 (DGLA) | 12 | 12 | 5.2 [4.9; 5.6) | 4.8 [4.6; 5.1] | −0.45 | [−1.144; 0.238] | 0.236 |
| C20:4n-6 (AA) | 12 | 12 | 2.9 [2.8; 3.1] | 2.5 [2.4; 2.9] | −0.19 | [−0.444; 0.062] | 0.186 |
| C20:5n-3 (EPA) | 12 | 12 | 0.04 [0.03; 0.05] | 0.04 [0.04; 0.04] | 0.002 | [−0.009; 0.012] | 0.765 |
| C22:4n-6 | 12 | 12 | 0.74 [0.67; 0.85] | 0.53 [0.49; 0.62] | −0.21 | [−0.313; −0.112] | 0.004** |
| C22:5n-6 | 12 | 12 | 0.86 [0.80; 1.02] | 0.70 [0.63; 0.90] | −0.17 | [−0.417; 0.069] | 0.200 |
| C22:5n-3 (DPA) | 12 | 12 | 0.69 [0.65; 0.78] | 0.64 [0.50; 0.65] | −0.13 | [−0.233; −0.035] | 0.031* |
| C22:6n-3 (DHA) | 12 | 12 | 0.26 [0.22; 0.27] | 0.27 [0.22; 0.32] | 0.01 | [−0.054; 0.078] | 0.732 |
| Total SFA | 12 | 12 | 49.3 [48.8; 49.8] | 48.5 [47.8; 49.0] | −0.77 | [−1.308; −0.241] | 0.024* |
| Total MUFA | 12 | 12 | 27.3 [26.2; 27.7] | 28.2 [27.5; 29.3] | 1.33 | [0.165; 2.491] | 0.058 |
| Total n-6 PUFA | 12 | 12 | 22.2 [27.8; 23.0] | 22.1 [21.3; 23.1] | −0.64 | [−1.814; 0.541] | 0.320 |
| Total n-3 PUFA | 12 | 12 | 1.2 [1.1; 1.2] | 1.1 [0.9; 1.2] | −0.13 | [−0.279; 0.019] | 0.127 |
| n-6/n-3 PUFA ratio | 12 | 12 | 19.2 [18.1; 19.7] | 19.1 [18.6; 24.2] | 1.88 | [−1.714; 5.464] | 0.335 |
| PUFA/SFA ratio | 12 | 12 | 0.47 [0.46; 0.49] | 0.48 [0.47; 0.49] | −0.004 | [−0.02; 0.012] | 0.653 |
Data are expressed as Median[Q1;Q3], in % of total FA. AA: C20:4n-6, arachidonic acid; ALA: C18:3n-3, alpha-linolenic acid; CI: Confidence Interval; DGLA: C20:3n-6, dihomo-gamma-linolenic acid; DHA: C22:6n-3, docosahexaenoic acid; DPA: C22:5n-3, docosapentaenoic acid; EPA: C20:5n-3, Eicosapentaenoic acid; GLA: C18:3n-6, gamma-linolenic acid; LA: C18:2n-6, linoleic acid; MUFA: monounsaturated fatty acids; PA: C16:0, palmitic acid; PL: phospholipids; PUFA: polyunsaturated fatty acids; SA: C18:0, stearic acid; SFA: saturated fatty acids “Statistics with *P < 0.05” and **P < 0.01.