Table 4.
Profile in fatty acid in F2 of control (CC) and exposed (EC) placenta NL at 28dpc (% of total fatty acids).
| Variable | Number of placenta | Median [Q1; Q3] | Fully adjusted linear model | ||||
|---|---|---|---|---|---|---|---|
| CC | EC | CC | EC | β value | CI | p-value | |
| C14:0 | 11 | 11 | 2.2 [2.1; 2.4] | 1.9 [1.8; 1.9] | −0.35 | [−0.51; −0.19] | 0.004** |
| C15:0 | 11 | 11 | 0.91 [0.84; 0.94] | 0.80 [0.69; 0.85] | −0.11 | [−0.19; −0.03] | 0.035* |
| C16:0 (PA) | 11 | 11 | 33.3 [32.4; 34.5] | 34.0 [32.0; 34.8] | 0.36 | [−1.51; 2.23] | 0.715 |
| Total C16:1 | 11 | 11 | 7.5 [7.0; 7.8] | 7.8 [7.4; 8.0] | 0.81 | [−0.48; 2.10] | 0.253 |
| C18:0 (SA) | 11 | 11 | 9.6 [9.2; 10.1] | 9.1 [8.7; 9.9] | −0.38 | [−0.99; 0.23] | 0.253 |
| C18:1n-7 | 11 | 11 | 3.1 [3.0; 3.3] | 3.2 [3.2; 3.4] | 0.27 | [0.06; 0.48] | 0.043* |
| C18:1n-9 (OA) | 11 | 11 | 22.6 [22.4; 24.7] | 26.6 [24.1; 27.4] | 3.06 | [0.74; 5.37] | 0.035* |
| Total C18:1 | 11 | 11 | 25.8 [25.4; 27.7] | 29.8 [27.4; 30.8] | 3.18 | [1.01; 5.35] | 0.023* |
| C18:2n-6 (LA) | 11 | 11 | 8.9 [8.6; 9.5] | 7.9 [6.7; 8.5] | −1.62 | [−2.76; −0.48] | 0.026* |
| C18:3n-3 (ALA) | 11 | 11 | 0.49 [0.46; 0.51] | 0.43 [0.36; 0.47] | −0.07 | [−0.14; −0.01] | 0.057 |
| C20:3n-6 (DGLA) | 11 | 11 | 5.0 [4.1; 6.3] | 4.1 [3.7; 4.6] | −1.04 | [−1.97; −0.10] | 0.064 |
| C20:4n-6 (AA) | 11 | 11 | 1.6 [1.4; 1.7] | 1.1 [1.0; 1.3] | −0.27 | [−0.46; −0.09] | 0.026* |
| C20:5n-3 (EPA) | 11 | 11 | 0.09 [0.08; 0.10] | 0.07 [0.06; 0.08] | −0.02 | [−0.04; −0.01] | 0.008** |
| C22:2n-6 | 11 | 11 | 0.17 [0.14; 0.21] | 0.13 [0.09; 0.14] | −0.05 | [−0.09; −0.01] | 0.047* |
| C22:4n-6 | 11 | 11 | 0.54 [0.38; 0.65] | 0.28 [0.26; 0.42] | −0.09 | [−0.21; 0.03] | 0.168 |
| C22:5n-6 | 11 | 11 | 0.17 [0.14; 0.21] | 0.12 [0.11; 0.18] | −0.04 | [−0.09; 0.02] | 0.256 |
| C22:5n-3 (DPA) | 11 | 11 | 0.22 [0.18; 0.24] | 0.16 [0.12; 0.23] | 0.01 | [−0.04; 0.07] | 0.643 |
| C22:6n-3 (DHA) | 11 | 11 | 0.04 [0.03; 0.09] | 0.04 [0.03; 0.05] | −0.03 | [−0.06; 0.002] | 0.104 |
| Total SFA | 11 | 11 | 46.3 [44.8; 47.6] | 45.5 [43.7; 47.0] | −0.03 | [−2.48; 2.41] | 0.978 |
| Total MUFA | 11 | 11 | 33.9 [33.3; 35.9] | 38.16 [36.0; 38.9] | 4.02 | [1.35; 6.68] | 0.02* |
| Total n-6 PUFA | 11 | 11 | 18.0 [16.4; 19.4] | 14.8 [14.4; 16.2] | −3.48 | [−5.55; −1.41] | 0.013* |
| Total n-3 PUFA | 11 | 11 | 1.8 [1.3; 1.9] | 1.7 [1.5; 1.8] | −0.02 | [−0.22; 0.18] | 0.876 |
| n-6/n-3 PUFA ratio | 11 | 11 | 10.5 [9.5; 13.6] | 9.0 [8.3; 10.0] | −2.07 | [−4.12; −0.03] | 0.085 |
| PUFA/SFA ratio | 11 | 11 | 0.45 [0.38; 0.46] | 0.35 [0.33; 0.41] | −0.07 | [−0.13; −0.02] | 0.039* |
Data are expressed as Median[Q1;Q3], in % of total FA. AA: C20:4n-6, arachidonic acid; ALA: C18:3n-3, alpha-linolenic acid; CI: Confidence Interval; DGLA: C20:3n-6, dihomo-gamma-linolenic acid; DHA: C22:6n-3, docosahexaenoic acid; DPA: C22:5n-3, docosapentaenoic acid; EPA: C20:5n-3, Eicosapentaenoic acid; LA: C18:2n-6, linoleic acid; MUFA: monounsaturated fatty acids; OA: C18:1n-9, oleic acid; PA: C16:0, palmitic acid; PL: phospholipids; PUFA: polyunsaturated fatty acids; SA: C18:0, stearic acid; SFA: saturated fatty acids “Statistics with *P < 0.05” and **P < 0.01.