Table 5.
Fatty acid profile in plasma in F2 of control (CC) and exposed (EC) fetuses at 28dpc (% of total fatty acids).
| Variable | Number of fetus | Median [Q1; Q3] | Fully adjusted linear model | ||||
|---|---|---|---|---|---|---|---|
| CC | EC | CC | EC | β value | CI | p-value | |
| C15:1n-9 | 12 | 12 | 0.16 [0.12; 0.22] | 0.28 [0.21; 0.29] | 0.10 | [0.04; 0.16] | 0.019* |
| C16:0 (PA) | 12 | 12 | 39.4 [37.7; 40.3] | 35.1 [31.5; 37.7] | −4.36 | [−7.18; −1.55] | 0.022* |
| Total C16:1 | 12 | 12 | 6.3 [6.0; 6.9] | 6.0 [5.3; 6.5] | −0.27 | [−1.15; 0.60] | 0.558 |
| C18:0 (SA) | 12 | 12 | 11.5 [11.2; 11.9] | 10.7 [10.3; 11.3] | −0.44 | [−2.20; 1.32] | 0.637 |
| C18:1n-7 | 12 | 12 | 2.0 [1.8; 2.1] | 1.5 [1.3; 1.6] | −0.39 | [−0.62; −0.17] | 0.013* |
| Total C18:1 | 12 | 12 | 22.6 [21.1; 23.1] | 18.5 [17.7; 22.5] | −1.64 | [−4.83; 1.54] | 0.346 |
| C20:0 | 12 | 12 | 0.13 [0.11; 0.15] | 0.80 [0.42; 1.15] | 0.58 | [0.18; 0.98] | 0.029* |
| C20:1n-9 | 12 | 12 | 0.38 [0.32; 0.46] | 1.33 [0.95; 2.03] | 1.02 | [0.59; 1.44] | 0.003** |
| C20:1n-7 | 12 | 12 | 0.07 [0.05; 0.08] | 0.475 [0.28; 0.70] | 0.40 | [0.23; 0.57] | 0.003** |
| Total C20:1 | 12 | 12 | 0.46 [0.39; 0.53] | 1.80 [1.23; 2.73] | 1.42 | [0.83; 2.00] | 0.003** |
| C18:2 n-6 (LA) | 12 | 12 | 11.1 [10.5; 12.1] | 9.1 [8.6; 9.9] | −1.70 | [−3.19; −0.21] | 0.065 |
| C18:3 n-3 (ALA) | 12 | 12 | 0.57 [0.44; 0.67] | 0.57 [0.49; 0.57] | −0.06 | [−0.27; 0.15] | 0.582 |
| C18:4n-3 | 12 | 12 | 0.18 [0.15; 0.28] | 0.32 [0.24; 0.51] | 0.16 | [0.07; 0.25] | 0.013* |
| C20:2n-6 | 12 | 12 | 0.34 [0.29; 0.39] | 0.62 [0.21; 0.93] | 0.29 | [0.04; 0.53] | 0.059 |
| C20:3n-6 (DGLA) | 12 | 12 | 0.49 [0.45; 0.57] | 0.36 [0.30; 0.42] | −0.13 | [−0.20; −0.06] | 0.012* |
| C20:4 n-6 (AA) | 12 | 12 | 2.6 [2.5; 2.8] | 1.6 [1.34; 1.83] | −1.03 | [−1.37; −0.69] | 0.001** |
| C20:4n-3 | 12 | 12 | 0.09 [0.06; 0.15] | 0.19 [0.10; 0.26] | 0.13 | [0.04; 0.22] | 0.032* |
| C20:5 n-3 (EPA) | 12 | 12 | 1.4 [0.01; 1.7] | 1.5 [0.05; 2.6] | 0.02 | [−0.97; 1.01] | 0.973 |
| C22:0 | 12 | 12 | 0.09 [0.07; 0.10] | 1.48 [0.71; 2.00] | 1.31 | [0.79; 1.83] | 0.003** |
| C22:1n-9 | 12 | 12 | 0.05 [0.04; 0.12] | 0.39 [0.35; 0.68] | 0.45 | [0.24; 0.66] | 0.006** |
| C22:4 n-6 | 12 | 12 | 0.12 [0.05; 0.16] | 1.85 [0.72; 4.22] | 2.12 | [1.23; 3.01] | 0.003** |
| C22:5 n-6 | 12 | 12 | 0.20 [0.16; 0.25] | 1.03 [0.35; 2.64] | 1.05 | [0.18; 1.91] | 0.054 |
| C22:5 n-3 (DPA) | 12 | 12 | 0.06 [0.04; 0.14] | 2.02 [0.80; 3.99] | 2.18 | [1.39; 2.96] | 0.002** |
| C22:6 n-3 (DHA) | 12 | 12 | 0.18 [0.16; 0.21] | 0.24 [0.15; 0.61] | 0.15 | [0.02; 0.27] | 0.055 |
| Total SFA | 12 | 12 | 52.8 [51.3; 54.1] | 50.2 [47.1; 52.5] | −2.11 | [−4.89; 0.67] | 0.184 |
| Total MUFA | 12 | 12 | 29.6 [28.1; 30.9] | 27.8 [26.2; 31.2] | −0.22 | [−3.42; 2.99] | 0.898 |
| Total n-6 PUFA | 12 | 12 | 15.7 [15.0; 17.0] | 16.3 [13.8; 17.7] | 0.49 | [−1.25; 2.23] | 0.599 |
| Total n-3 PUFA | 12 | 12 | 1.8 [1.1; 2.8] | 4.3 [1.8; 7.5] | 2.53 | [0.47; 4.58] | 0.051 |
| n-6/n-3 PUFA ratio | 12 | 12 | 9.4 [5.6; 15.1] | 3.8 [2.5; 7.6] | −7.68 | [−10.84; −4.52] | 0.005** |
| PUFA/SFA ratio | 12 | 12 | 0.33 [0.31; 0.36] | 0.41 [0.30; 0.56] | 0.09 | [0.004; 0.17] | 0.084 |
Data are expressed as Median[Q1;Q3], in % of total FA. AA: C20:4n-6, arachidonic acid; ALA: C18:3n-3, alpha-linolenic acid; DGLA: C20:3n-6, dihomo-gamma-linolenic acid; DHA: C22:6n-3, docosahexaenoic acid; DPA: C22:5n-3, docosapentaenoic acid; EPA: C20:5n-3, Eicosapentaenoic acid; LA: C18:2n-6, linoleic acid; MUFA: monounsaturated fatty acids; PA: C16:0, palmitic acid; PL: phospholipids; PUFA: polyunsaturated fatty acids; SA: C18:0, stearic acid; SFA: saturated fatty acids “Statistics with *P < 0.05” and **P < 0.01.