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. 2019 Jul 4;9:9666. doi: 10.1038/s41598-019-46132-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis of miR-21 and miR-26b fold-change in patients under TKI treatment. miR-21 (a) and miR-26b (b) fold-change were analysed according to the number of TKI that patients were exposed. The miR-26 expression levels were also studied in patients stratified according to BCR-ABL1 values (c) and to molecular response rates (d) Higher levels of miR-21 and miR-26b were detected in patients that fail 1^st line of treatment, whereas miR-26b were down-regulated in patients with lower BCR-ABL1 levels and also in patients with deeper responses to treatment (MR 4.0 and MR 4.5). Statistical differences between groups are reported by the p-value.