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. 2019 Jul 4;9:9649. doi: 10.1038/s41598-019-46030-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Example of correction technique for feature glrl3d-rl_NonUniformity using a surface fit. (a) With testing dataset, the percentage change in feature value from the 2.7 mm result was plotted against feature value and voxel size for each patient. (b) Validation dataset plotted for feature. (c) Applying the correction to the validation dataset using Eq. (1).