. 2019 Jul 4;9:9718. doi: 10.1038/s41598-019-46142-7

Table 1.

The 59 proteins detected in milk during early lactation (i.e., 6 to 21 DIM).

No.	Gene Name	Protein ID	Protein name	Milk fraction localization	References
1	ABCC4	A0JND8_BOVIN	ABCC4 protein	MFGM	¹⁰
2	ACAT1	THIL_BOVIN	Acetyl-CoA acetyltransferase, mitochondrial	Skimmed	^13, 17
3	ALDH3B1	AL3B1_BOVIN	Aldehyde dehydrogenase family 3 member B1	Skimmed	¹⁰
4	ALOX12	Q6SYC4_BOVIN	Arachidonate 12-lipoxygenase	MFGM	¹⁰
5	ARL6IP5	PRAF3_BOVIN	PRA1 family protein 3	Skimmed	^13, 17
6	ATP5F1^a	AT5F1_BOVIN	ATP synthase F(0) complex subunit B1, mitochondrial	Skimmed	^13, 17
7	ATP5H^a	ATP5H_BOVIN	ATP synthase subunit d, mitochondrial	Skimmed	^13, 17
8	ATP5J^a	ATP5J_BOVIN	ATP synthase-coupling factor 6, mitochondrial	Skimmed	^13, 17
9	ATP5J2^a	ATPK_BOVIN	ATP synthase subunit f, mitochondrial	Skimmed	^13, 17
10	BAT1	Q861P7_BOVIN	HLA-B-associated transcript 1	Skimmed	¹³
11	Bt.64131	F1MIR4	RAB2A, member RAS oncogene family	MFGM	¹⁰
12	C13H20ORF116^a	Q1LZB0_BOVIN	Chromosome 20 open reading frame 116 ortholog	Skimmed	¹³
13	C1QBP	C1QBP_BOVIN	Complement component 1 Q subcomponent-binding protein, mitochondrial	Skimmed	^13, 17
14	CAT	CATA_BOVIN	Catalase	Skimmed	^13, 17
15	COPG	Q0V888_BOVIN	Coatomer protein complex, subunit gamma 1	Skimmed	^13, 17
16	COX5A	COX5A_BOVIN	Cytochrome c oxidase subunit 5A, mitochondrial	Skimmed	^13, 17
17	COX5B	COX5B_BOVIN	Cytochrome c oxidase subunit 5B, mitochondrial	Skimmed	^13, 17
18	COX7A2	CX7A2_BOVIN	Cytochrome c oxidase subunit 7A2, mitochondrial	Skimmed	^13, 17
19	CUZD1^a	F1MD73	Uncharacterized protein	MFGM	¹⁰
20	DDRGK1	DDRGK_BOVIN	DDRGK domain-containing protein 1	Skimmed	^13, 17
21	DDX39B	DX39B_BOVIN	Spliceosome RNA helicase DDX39B	Skimmed	¹⁷
22	EEF1B	EF1B_BOVIN	Elongation factor 1-beta	Skimmed	^13, 17
23	GPAM	GPAT1_BOVIN	Glycerol-3-phosphate acyltransferase 1, mitochondrial	MFGM	¹⁰
24	HIST1H4A^a	P62803	Histone 4	MFGM	¹⁰
25	IG^a	A5D7Q2	Uncharacterized protein	MFGM	¹⁰
26	IVD	IVD_BOVIN	Isovaleryl-CoA dehydrogenase, mitochondrial	Skimmed	^13, 17
27	LF	Q95M55_BOVIN	Lactoferrin	MFGM	¹⁰
28	LMAN1	Q8MJ82_BOVIN	Lectin mannose binding 1	Skimmed	^13, 17
29	LOC789567	A6H7H3_BOVIN	LOC789567 protein	Skimmed	^13, 17
30	LRPAP1	Q148K7_BOVIN	Low density lipoprotein receptor-related protein associated protein 1	Skimmed	^13, 17
31	LRRC59	LRC59_BOVIN	Leucine-rich repeat-containing protein 59	Skimmed	^13, 17
32	Man8	O78186_BOVIN	MHC class I antigen	MFGM	¹⁰
33	MGC137099	Q2KII3_BOVIN	Hepatitis A virus cellular receptor 1 N-terminal domain containing protein	MFGM	¹⁰
34	MYCBP	MYCBP_BOVIN	c-Myc-binding protein	Skimmed	^13, 17
35	NDUFA5	NDUA5_BOVIN	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	Skimmed	^13, 17
36	NDUFAB1	ACPM_BOVIN	Acyl carrier protein, mitochondrial	Skimmed	^13, 17
37	OSTC	OSTC_BOVIN	Oligosaccharyltransferase complex subunit OSTC	Skimmed	¹³
38	PAFAH1B2	PA1B2_BOVIN	Platelet-activating factor acetylhydrolase IB subunit beta	Skimmed	^13, 17
39	PCK2	F1MDS3_BOVIN	Phosphoenolpyruvate carboxykinase 2, mitochondrial	Skimmed	^13, 17
40	PLSCR2	PLS2_BOVIN	Phospholipid scramblase 2	MFGM	¹⁰
41	RPL10A	RL10A_BOVIN	60S ribosomal protein L10a	Skimmed	^13, 17
42	RPL18	RL18_BOVIN	60S ribosomal protein L18	Skimmed, MFGM	^10, 13, 17
43	RPL6	RL6_BOVIN	60S ribosomal protein L6	Skimmed	^13, 17
44	RPL7	RL7_BOVIN	60S ribosomal protein L7	Skimmed	^13, 17
45	RPL7A	RL7A_BOVIN	60S ribosomal protein L7a	Skimmed	^13, 17
46	RPS13	RS13_BOVIN	40S ribosomal protein S13	Skimmed	^13, 17
47	SAA	P35541	Serum amyloid A protein	MFGM	¹⁰
48	SDHA	SDHA_BOVIN	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	Skimmed	^13, 17
49	SEC. 11C	Q2KI36_BOVIN	Signal peptidase complex catalytic subunit SEC. 11	Skimmed	^13, 17
50	SEC. 61A1	S61A1_BOVIN	Protein transport protein Sec. 61 subunit alpha isoform 1	Skimmed	^13, 17
51	SLC15A2	B8Y6C2_BOVIN	Solute carrier family 15 member 2	MFGM	¹⁰
52	SSR1	SSRA_BOVIN	Translocon-associated protein subunit alpha	Skimmed	^13, 17
53	SURF4	SURF4_BOVIN	Surfeit locus protein 4	Skimmed	^13, 17
54	SYPL1	A8PVV5_BOVIN	SYPL1 protein	Skimmed	^13, 17
55	TMED9	TMED9_BOVIN	Transmembrane emp24 domain-containing protein 9	Skimmed	^13, 17
56	TMEM43	A6QQR5_BOVIN	TMEM43 protein	Skimmed	^13, 17
57	TREM1	TREM1_BOVIN	Triggering receptor expressed on myeloid cells 1	Skimmed	^13, 17
58	TXNDC4^a	TXND4_BOVIN	Thioredoxin domain-containing protein 4	Skimmed	¹³
59	UQCRC1	QCR1_BOVIN	Cytochrome b-c1 complex subunit 1, mitochondrial	Skimmed	^13, 17

^aUpdated since the period of data mining. The Gene name and ID were converted before November 2018 by use of the Retrieve/ID Mapping tool of the Uniprot database.