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. 2019 Jul 4;9:9715. doi: 10.1038/s41598-019-46064-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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HSPB8 expression is downregulated in metastatic prostate cancer. (a) Comparison of AR, HOXB13, and HSPB8 gene expression in bone metastatic CRPCs (GSE101607) **p < 0.005, ****p < 0.0005. (b) GSE6752 which comprised 10 primary and 21 androgen ablation resistant metastatic samples. ****p < 0.0005. (c) GSE67980 (human primary and metastatic cases) ***p < 0.005; *p < 0.05. ns = not significant. (d) Moffitt TCC primaries. ****p < 0.0005; *** p < 0.005. (e) Moffitt TCC metastasis. ****p < 0.0005. (f) Moffitt TCC Data Set. ****p < 0.0005. (g) AR/HOXB13 co-expression is observed in 94 (63%) of metastatic PC cases (SU2C/PCF cohort, Cell 2015). HSPB8 expression inversely correlates with AR and HOXB13 expression. Pearson co-relation co-efficient and Spearman rank co-efficient are shown below each panel.