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. 2019 Jul 4;9:9711. doi: 10.1038/s41598-019-45910-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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An RNAi based screen for DENV2 human host factors. (A) Schematic describing the RNAi screen work flow. (B) Representative images from control wells. Infected cells are green and nuclei are blue. Rates of infection across the screen are indicated for each control. (C) Behavior of all control wells across the screen in terms of infection percentage. (D) Each point represents infection rate for wells AB and CD for a given gene. The 455 hits are highlighted in lower left corner. (E) Same data as in panel D plotted in deciles. The color represents numbers of genes in each square. (F) Venn diagram indicating numbers of host factor genes commonly identified between DENV and YFV RNAi screens, and identified by meta-analysis of both screens (see Materials and Methods).