Table 2.
The top four metabolite ratios that associated with the percentage of the lateral cartilage volume loss at 24 months.
| Metabolite ratios | Unadjusted* | Adjusted** | ||
|---|---|---|---|---|
| β (95% CI) | P value | β (95% CI) | P value | |
| LysoPC 18:2/PC44:3 | −0.21 (−0.30; −0.13) | 8.5*10−7 | −0.18 (−0.27; −0.10) | 4.5*10−6 |
| LysoPC18:1/PC44:3 | −0.28 (−0.40; −0.16) | 1.3*10−5 | −0.25 (−0.37; −0.13) | 1.5*10−5 |
| Glutamine/PC44:3 | −0.28 (−0.40; −0.16) | 1.9*10−5 | −0.28 (−0.40; −0.16) | 3.6*10−6 |
| Methionine/proline | 0.09 (0.05; 0.12) | 3.0*10−5 | 0.07 (0.04; 0.11) | 6.9*10−5 |
*Associations were tested by using linear regression model. **Covariates including age, sex, BMI, diabetes, hypertension, dyslipidemia, and treatment were included in the multivariable linear regression model. β stands for percentage change in cartilage volume at 24 months per unit increase for a given ratio. For example, lateral cartilage volume was reduced by 0.21% at 24 months for one unit increase of the ratio of the Z-scores of lysoPC 18:2 and PC 44:3.
LysoPC 18:2: lysophosphatidylcholine with 18 carbons and 2 double bonds; PC44:3: phosphatidylcholine with 44 carbons and 3 double bonds; lysoPC 18:1: lysophosphatidylcholine with 18 carbons and 1 double bond.