Table 3.
The top metabolite ratios that associated with the percentage of the medial cartilage volume loss at 24 months.
| Metabolite ratios | Unadjusted* | Adjusted** | ||
|---|---|---|---|---|
| β (95% CI) | P value | β (95% CI) | P value | |
| PC32:1/PC40:5 | 0.30 (0.16; 0.44) | 2.5*10−5 | 0.30 (0.16; 0.43) | 5.7*10−6 |
| PC32:2/PC40:5 | 0.21(0.11; 0.30) | 5.1*10−5 | 0.20 (0.11; 0.30) | 1.1*10−5 |
| PC42:0/PC40:5 | 0.26 (0.14; 0.38) | 5.4*10−5 | 0.26 (0.14; 0.38) | 7.5*10−6 |
| PC34:1/PC40:5 | 0.18 (0.09; 0.27) | 5.7*10−5 | 0.19 (0.10; 0.27) | 4.5*10−6 |
*Associations were tested by using linear regression model. **Covariates including age, sex, BMI, diabetes, hypertension, dyslipidemia, and treatment were included in the multivariable linear regression model. β stands for percentage change in cartilage volume at 24 months per unit increase for a given ratio.
PC: phosphatidylcholine; first number represents the total number of carbons in the PC and the second number stands for the number of the double bonds in the compound.