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. 2019 Jun 18;110(7):2296–2308. doi: 10.1111/cas.14041

Figure 6.

Figure 6

Vasohibin‐2 (Vash2) modulated the expression of inflammatory chemokines and cytokines in pancreatic ductal adenocarcinoma (PDAC) cells. A, Pathway enrichment analysis (by Metascape) of genes downregulated by Vash2 knockdown in KPC cells. B, Quantification of nuclear factor kappa B (NF‐kB) activity in KPC/shControl and KPC/shVash2 clones using luciferase reporter assay. (n = 3). C, Quantification of chemokine and cytokine mRNA expression in KPC/shControl and KPC/shVash2 clones (n = 3). D, Quantification of chemokine and cytokine mRNA expression in the PDAC of KPC mice and KPC/Vash2 LacZ/LacZ mice (n = 7). Error bars represent SEM (B, C) and SD (D). *P < .05, **P < .01. NS, not significant