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. 2019 Jun 6;11(7):e10293. doi: 10.15252/emmm.201910293

Figure EV5. Systemic CD8 responses in NSCLC patients.

Figure EV5

  1. Percentage of circulating highly differentiated CD8 cells in age‐matched healthy donors (n = 40) and NSCLC patients (n = 51) before undergoing immunotherapies. Relevant statistical comparisons are shown by the test of Mann–Whitney. In green, objective responders (OR). In red, no OR.
  2. ROC analysis of baseline CD8 THD quantification as a function of objective clinical responses.
  3. Dot‐plot of lung cancer antigen‐specific CD8 T cells obtained before the start of immunotherapies and stimulated with A549‐loaded autologous DCs autologous DC in healthy donors (n = 5), G1 (n = 11) and G2 (n = 13) patients, as indicated. Relevant statistical comparisons are indicated by the test of Kruskal–Wallis.
  4. Left dot‐plot, percentage of CD28‐negative CD8 T cells within TAA‐specific CD8 subsets in G1 (n = 11) and G2 (n = 13) patients, as indicated. Right dot‐plot, same as left but with CD28‐positive subsets. Green, objective responders (OR) and red, no ORs. N, number of biological replicates (independent patients).