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. 2019 Jun 6;11(7):e10201. doi: 10.15252/emmm.201810201

Figure 4. PARN KO cells display telomere instability independently of telomere length.

Figure 4

  1. Analysis of telomeric aberrations by Telo‐FISH in doxycycline‐treated WT/empty, WT/PARN, KO/empty, and KO/PARN cells. Two independent experiments were performed. Counted chromatids: WT/empty: n = 1,824; WT/PARN: n = 1,744; KO/empty: n = 1,452; KO/PARN: n = 1,920. Averages are shown, and chi‐square tests were applied to compare KO/empty with either WT/empty or KO/PARN.
  2. TRF analysis of telomere length (kb) in KO/empty and KO/PARN cells treated with 10 ng/ml Dox for 72 h. A control Western blot with PARN and actin is shown below for the corresponding samples.