Table 2.
Immunological features of patients
| Age | Patient 1 | Patient 2 | |||
|---|---|---|---|---|---|
| 9 years | 11 years | 6 months | 10 months | 23 months | |
| White cell count—×109/l | 2.7 (5.5–15.5) | 3.3 (5.5–15.5) | 8.8 (6–17.5) | 6.7 (6–17.5) | 3.1 (6–17.5) |
| Polymorphonuclear neutrophils—×109/l | 1.1 (1.8–8.0) | 1.4 (1.8–8.0) | 3.0 (1.5–8.5) | 3.2 (1.5–8.5) | 0.8 (1.5–8.5) |
| Lymphocytes—×109/l | NA | NA | 4.4 (3.0–9.5) | 2.3 (3.0–9.5) | 2.2 (3.0–9.5) |
| Hemoglobin—g/dl | 10 (11.5–13.5) | 7.1 (11.5–13.5) | 11.9 (10.5–12.0) | 12.1 (10.5–12.0) | 7.3 (10.5–12.0) |
| Platelets—×109/l | 29 (175–420) | 37 (175–420) | 67 (175–500) | 38 (175–500) | 5 (175–500) |
| Reticular platelets—% | NA | NA | NA | 6.5 (1.0–7.0) | NA |
| T cells—% (normal range) | |||||
| CD3+ | 88 (60–76) | 92 (60–76) | 73 (49–76) | 84 (49–76) | NA |
| CD4+ | 47 (31–47) | 31 (31–47) | 40 (31–56) | 41 (31–56) | NA |
| CD31+CD45RA/CD4+ | 27 (43–55) | NA | NA | 37 (60–72) | NA |
| CD8+ | 41 (18–35) | 59 (18–35) | 15 (12–24) | 33 (12–24) | NA |
| B CD19+ cells – % | 0.1 (13–27) | 2 (13–27) | 19 (14–37) | 12 (14–37) | NA |
| Natural killer CD16+CD56+ cells — % | 0.1 (4–17) | NA | 7 (3–15) | 4 (3–15) | NA |
| Serum immunoglobulins level: g/l | |||||
| IgG | NA | 9.76 (6.55–12.29) | 3.35 (3.35–6.23) | 5.30 (3.35–6.23) | NA |
| IgA | NA | 1.74 (0.5–2.03) | 0.41 (0.27–0.86) | 0.43 (0.27–0.86) | NA |
| IgM | NA | 1.21 (0.53–1.62) | 1.27 (0.48–1.36) | 0.52 (0.48–1.36) | NA |
For all values, normal range or normal thresholds are indicated in brackets. Abnormal low values are highlighted in bold.
NA, not available.