Table 2.
Prevalence of individual major and accessory integrase resistance mutations and combination of them in a cohort of raltegravir failing patients in Buenos Aires, Argentina (N = 57).
| N (%) | |
|---|---|
| Major mutations | |
| N155H | 20 (35.1) |
| Q148HR | 9 (15.8) |
| G140AS | 8 (14) |
| E138A | 3 (5.3) |
| Y143R | 3 (5.3) |
| T66A | 1 (1.8) |
| E92Q | 1 (1.8) |
| Accesory mutations | |
| G163KR | 18 (31.6) |
| T97A | 11 (19.3) |
| V151I | 8 (14) |
| L74IM | 5 (8.8) |
| E157Q | 2 (3.5) |
| A128T | 1 (1.8) |
| Combined mutations | |
| G190A/S + Q148H/R | 6 (10.5) |
| N155H + G163K/R | 4 (7) |
| A128T + V151I + N155H | 1 (1.7) |
| E138A/E + G140A/S + Q148H/R | 1 (1.7) |
| E92A/E + T97A + V151I + N155H | 1 (1.7) |
| L68V + L74M + E92Q + T97A + N155H | 1 (1.7) |
| L74I + V151I + N155H + G163R | 1 (1.7) |
| L74I + Y143R + V151I + N155H | 1 (1.7) |
| L74M + T97A + Y143R + G163R | 1 (1.7) |
| Q148H/R + G163R | 1 (1.7) |
| T66A/T + L74I + T97A + E138A/E | 1 (1.7) |
| T79A + G163R | 1 (1.7) |
| T97A + E138A/E + Y143R + G163K | 1 (1.7) |
| T97A + G140AS + Q148HR | 1 (1.7) |
| T97A + G163R | 1 (1.7) |
| T97A + N155H | 1 (1.7) |
| T97A + N155H + G163R | 1 (1.7) |
| V151I + N155H + E157Q | 1 (1.7) |
| V151I + N155H + E157Q +G163R | 1 (1.7) |
| V151I + N155H | 1 (1.7) |