Table 2.
Longitudinal associations/correlations of SBP, DBP, and UACR with baseline SUA and hyperuricemia in multivariable models*
| SBP (mmHg) | DBP (mmHg) | UACR (mg/g) | |
|---|---|---|---|
| Baseline SUA (per 1 mg/dL) | |||
| Model 1—without adjustment for insulin sensitivity | |||
| β ± SE or % change | 0.81 ± 0.25 | 0.61 ± 0.21 | 10.2 |
| P value | 0.0013 | 0.0041 | 0.0030 |
| Model 2—with adjustment for insulin sensitivity | |||
| β ± SE or % change | 0.77 ± 0.25 | 0.60 ± 0.21 | 10.3 |
| P value | 0.0024 | 0.0046 | 0.0028 |
| Baseline hyperuricemia (≥6.8 mg/dL vs. not) | |||
| Model 1—without adjustment for insulin sensitivity | |||
| Mean difference ± SE or % difference in means | 2.59 ± 0.78 | 1.91 ± 0.65 | 26.3 |
| P value | 0.0009 | 0.0037 | 0.0133 |
| Model 2—with adjustment for insulin sensitivity | |||
| Mean difference ± SE or % difference in means | 2.50 ± 0.78 | 1.92 ± 0.66 | 27.4 |
| P value | 0.0014 | 0.0036 | 0.0098 |
*Measures of correlation over time are presented from linear mixed models adjusted for baseline eGFR, age, HbA1c, BMI, sex, race/ethnicity, randomized treatment group, and antihypertensive medication use before and after adjustment for insulin sensitivity. For the models relating baseline SUA to SBP and DBP, data are β estimate ± SE; for models relating baseline SUA to UACR (log-transformed before testing), data are percentage change in UACR per unit change in baseline SUA; for those relating baseline hyperuricemia to the outcomes, data are the difference in means in SBP or DBP or the percentage difference in geometric mean in UACR between the two SUA groups (≥6.8 mg/dL vs. not). P values between outcome and exposure are also shown.