Table 1.
Variable | N (%*) or median (range) |
---|---|
Total | 30 (100) |
Age, y | 33 (20-69) |
Sex | |
Male | 16 (53) |
Female | 14 (47) |
Frontline therapy | |
A(B)VD† | 24 (80) |
BV-A(B)VD | 1 (3) |
ABVE-PC | 1 (3) |
BEACOPP‡ | 2 (7) |
RCHOP/REPOCH | 2 (7) |
Prior brentuximab exposure | 6 (20) |
Prior nivolumab or pembrolizumab exposure | 6 (20) |
Prior radiotherapy | 7 (23) |
Conditioning regimen | |
BEAM | 30 (100) |
Risk factors | |
Primary refractory disease | 17 (57) |
Relapse within 12 mo | 5 (17) |
Extranodal disease at relapse | 8 (27) |
At least 1 of above 3 factors | 26 (87) |
Residual disease after salvage | 3 (10) |
B symptoms at relapse | 2 (7) |
>1 salvage therapy | 5 (17) |
At least 1 of above 6 factors | 27 (90) |
At least 2 of above 6 factors | 12 (40) |
Disease status at study entry (post-ASCT) | |
Partial remission | 2 (7) |
Complete remission | 28 (93) |
A(B)VD, doxorubicin, bleomycin, vinblastine, and dacarbazine; ABVE-PC, doxorubicin, bleomycin, vincristine, etoposide, prednisone, cyclophosphamide; BEACOPP, bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone; BEAM, carmustine, etoposide, cytarabine, and melphalan; BV, brentuximab vedotin; RCHOP, rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone; REPOCH, rituximab plus etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin.
Percentages may not add to 100 because of rounding.
With rituximab in 1 patient.
Given after ABVD in 1 additional patient.