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. 2019 May 2;68(7):1462–1472. doi: 10.2337/db18-1175

Figure 6.

Figure 6

Central, but not peripheral, FGF1 induced c-Fos activation of third ventricle α-tanycytes. A–C: c-Fos activation of third ventricle tanycytes 90 min after subcutaneous administration of FGF1 (filled bars, F) or vehicle (open bars, V) in control (A), DIO (B), and db/db (C) mice. c-Fos activation of third ventricle tanycytes 90 min after intracerebroventricular injection of FGF1 or vehicle in control (D), DIO (E), and db/db (F) mice. n = 3 per group. Data are expressed as mean ± SEM. P values were determined by two-way ANOVA. ***P < 0.001; ****P < 0.0001. i.c.v., intracerebroventricular; sc, subcutaneous.