Figure 6.
GLO1 improved diabetic BMPC therapy in wound healing in type 2 diabetic mice. For cell therapies, 1 × 106 db/db BMPCs infected with Ad-GLO1 or Ad-GFP were transplanted onto db/db wounds. A: Wound closure curves in db/db mice that received BMPC therapies (n = 5 per group). B: Representative images of cutaneous wounds taken on days 0, 6, 10, and 16 after wounding. C: Capillary formation as evaluated by CD31 staining (brown) in wounds that received cell therapies. Arrows indicate capillary-like structures at wound edge. Images on right are amplified from the region marked with a square on the left. *P < 0.05 vs. db/db plus Ad-GFP; #P < 0.05 vs. db/+ plus GFP.