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. 2019 Apr 1;68(6):1341–1352. doi: 10.2337/db18-0796

Figure 2.

Figure 2

Selective activation of M3Dq in SKM improves glucose tolerance and insulin sensitivity in mice in vivo. A and B: IGTT. SKM-M3Dq mice (M3Dq) and WT control littermates were injected with glucose (2 g/kg i.p.) (A) or glucose (2 g/kg i.p.) plus CNO (1 mg/kg i.p.) (B). C and D: ITT. SKM-M3Dq mice (M3Dq) and WT control littermates were injected with insulin (1.5 units/kg i.p.) (C) or insulin (1.5 units/kg i.p.) plus CNO (1 mg/kg i.p.) (D). E: Glucose-stimulated insulin secretion (GSIS). SKM-M3Dq mice (M3Dq) and WT control littermates were injected with glucose (2 g/kg i.p.) plus CNO (1 mg/kg i.p.). Data are given as means ± SEM (n = 5 or 6 mice/group). *P < 0.05, **P < 0.01 vs. WT (Student t test).