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Metabolic studies with SKM-M3Dq mice that express a DN version of AMPK in SKM (M3Dq/AMPK-DN mice). A: IGTT. SKM-M3Dq mice (M3Dq), M3Dq/AMPK-DN mice, and WT control littermates were injected i.p. with glucose (2 g/kg) plus CNO (1 mg/kg). B: ITT. The same mice as used in A were injected i.p. with insulin (1.5 units/kg) plus CNO (1 mg/kg). Data are given as means ± SEM (n = 4–8 mice/group). *P < 0.05 vs. WT (Student t test).
