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. 2019 Mar 20;68(6):1210–1220. doi: 10.2337/db18-1167

Figure 3.

Figure 3

Changes of the levels of gene expressions in the hypothalamus by celastrol. A–D: Expression levels of genes involved in ER stress. E–G: Expression levels of inflammatory cytokine genes. H–J: Expression levels of neuropeptides involved in homeostatic regulation of energy balance. K–M: Expression levels of genes involved in leptin signaling. N: pPERK and SERCA2 protein levels in the hypothalamus. Data are presented as mean ± SEM. *P < 0.05, **P < 0.01 by Student t test compared with vehicle group.