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Celastrol treatment (0.5 mg/kg) increases RMR. A: Body weight when mice subjected to RMR measurement. Changes of RMR (ΔRMR) (B) and RER (ΔRER) (C) from baseline in both chow-fed WT and DIO mice. N = 6–9/group. Data are presented as mean ± SEM. *P < 0.05 by two-way ANOVA compared with vehicle group.
