Table 2.

Glucose, insulin, and C-peptide ΔAUC over the first 120 min after gavage of a 0.9 g/kg glucose load in conscious dogs fasted for 18 h at baseline (chow fed, n = 8) after 4 weeks of HFHF diet (pre-SHAM, n = 9; pre-CHADN, n = 11), 2.5 and 3.5 weeks postsurgery (post-SHAM, n = 9; post-CHADN, n = 11), 7.5 weeks postsurgery (post-SHAM, n = 4; post-CHADN, n = 5), and 11.5 weeks postsurgery (post-SHAM, n = 4; post-CHADN, n = 5)

Chow	Group	ΔAUC			Ratio of ΔAUC
		Glucose (mg/120 min/dL)	Insulin (μU/120 min/mL)	C-Peptide (mg/120 min/mL)	Insulin/glucose	C-Peptide/glucose
	Baseline (n = 8)	3,215 ± 352	1,671 ± 191	47 ± 4	0.52 ± 0.12	0.015 ± 0.001
4 weeks on HFHF diet	Pre-SHAM (n = 9)	6,341 ± 289†	2,586 ± 756†	78 ± 29†	0.40 ± 0.12	0.012 ± 0.004†
	Pre-CHADN (n = 11)	7,580 ± 2,418‡	2,185 ± 1,062‡	73 ± 20‡	0.31 ± 0.2‡	0.010 ± 0.004‡
2.5–3.5 weeks postsurgery	Post-SHAM (n = 9)	6,458 ± 2,583†	2,295 ± 475†	66 ± 15†	0.30 ± 0.20†	0.012 ± 0.005†
	Post-CHADN (n = 11)	5,104 ± 2,059	2,309 ± 1,322‡	69 ± 29‡	0.48 ± 0.25	0.014 ± 0.004
7.5 weeks postsurgery	Post-SHAM (n = 4)	6,413 ± 2,568†	2,222 ± 333†	81 ± 13†	0.34 ± 0.20†	0.012 ± 0.005†
	Post-CHADN (n = 5)	4,720 ± 629	1,996 ± 977‡	70 ± 13‡	0.42 ± 0.15	0.015 ± 0.003
11.5 weeks postsurgery	Post-SHAM (n = 4)	5,657 ± 1,063†	2,088 ± 812†	68 ± 16†	0.36 ± 0.10	0.012 ± 0.005†
	Post-CHADN (n = 5)	4,940 ± 1,509	2,139 ± 662‡	67 ± 12‡	0.43 ± 0.19	0.015 ± 0.006

Values are the mean ± SD. Ratios of the ΔAUC for insulin over the ΔAUC for glucose and of the ΔAUC for C-peptide over the ΔAUC for glucose represent the amount of insulin and C-peptide secreted in response to glucose appearing in the circulation. ΔAUC values were calculated by subtracting the baseline AUC from the AUC for each condition between 0 and 120 min.

†P < 0.05 SHAM vs. baseline.

‡P < 0.05 CHADN vs. baseline (two-way ANOVA with post hoc analysis by Student-Newman-Keuls model).