Table 3.

Tracer-determined unidirectional HGU as well as production and NHGB during an HIHG clamp in conscious dogs fasted for 18 h fed a chow or HFHF diet for 8 weeks

	Basal period	Experimental period
HGU
Chow-CTRL	0.3 ± 0.2	1.6 ± 0.2
HFHF + SHAM	0.3 ± 0.2	0.4 ± 0.3†
HFHF + CHADN	0.3 ± 0.2	0.8 ± 0.4*,‡
HGP
Chow-CTRL	1.9 ± 0.4	0.1 ± 0.5
HFHF + SHAM	1.8 ± 0.6	0.5 ± 0.7
HFHF + CHADN	1.9 ± 0.8	0.2 ± 0.6
NHGB
Chow-CTRL	1.6 ± 0.3	−1.5 ± 0.8
HFHF + SHAM	1.5 ± 0.5	0.1 ± 0.4†
HFHF + CHADN	1.6 ± 0.5	−0.5 ± 0.3*

Values are means of the last 60 min of the experimental period ± SD in mg/kg/min. Negative values for balance data indicate net hepatic uptake. CHADN animals underwent sympathetic CHADN after 4.5 weeks of diet, while SHAM dogs underwent a sham procedure at the same time. The clamp was carried out 3.5 weeks after surgery. CTRL, control.

*P < 0.05 for HFHF + SHAM vs. HFHF + CHADN.

†P < 0.05 for HFHF + SHAM vs. CTRL.

‡P < 0.05 for HFHF + CHADN vs. CTRL.