Table III.

Mutations of tumor tissue from ten biliary tract cancer patients.

Patient ID	SNV/Indel			CNV
Patient #1	TP53	p.Q38Pfs*5	0.30a	CDK12	Gain
	CDH1	p.Q610*	0.07	ERBB2	Gain
				CCNE1	Gain
				CDKN2A	Loss
Patient #2	TP53	p.C275F	0.22	FGFR2	Gain
	TP53	p.P27Lfs*17	0.10
	ARID2	p.Q794Cfs*45	0.11
Patient #3	TP53	p.P151T	0.22
Patient #4	TP53	p.V157F	0.49	CCNE1	Gain
	FLT4	p.A622T	0.21	CDKN2A	Loss
Patient #5	TP53	c.783-2_821del	0.07
	CDKN2A	p.V82E	0.19
	KRAS	p.I36M	0.35
Patient #6	TP53	p.M237I	0.08	MSH6	Loss
	PDGFRA	p.L216I	0.12
	NF1	p.E649*	0.08
	RNF43	p.L706Cfs*20	0.07
Patient #7	KRAS	p.G12D	0.19
	ATM	p.A2626V	0.16
Patient #8	TP53	p.R248W	0.24	FGFR3	Gain
	TSC1	p.R190H	0.23	VEGFA	Gain
				MYC	Gain
				ERBB3	Loss
Patient #9				MRE11A	Gain
				MTOR	Loss
				CDKN2A	Loss
				STK11	Loss
Patient #10				MTOR	Gain
				SPEN	Gain
				NOTCH1	Gain
				GNA11	Gain

^aMutation allele frequency in DNA sample from tumor tissue. SNV/Indel, single nucleotide variation/insertion and deletion; CNV, copy number variation.