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. 2019 Jun 11;42(2):571–580. doi: 10.3892/or.2019.7194

Figure 2.

Figure 2.

High dose imatinib increases the RRM2 level in imatinib-resistant (IR) cells. We treated K562G cells with 8, 10 and 12 µM imatinib, and K562 cells with 2 µM imatinib. The RRM2 mRNA and protein levels were analyzed using RT-PCR, qF-PCR and western blot analysis. (A) RT-PCR results. (B) qF-PCR results. (C) Western blot analysis results and the relative band density. (D) RT-PCR results showed that 2 µM imatinib did not significantly alter the mRNA level of RRM2 in imatinib-sensitive (IS) cells. CT, K562 cells used as the control. One-way ANOVA, **P<0.01, compared with the CT group. #P<0.05, ##P<0.01. NS, not significant; RRM2, ribonucleotide reductase regulatory subunit M2.