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. 2019 Jun 11;42(2):571–580. doi: 10.3892/or.2019.7194

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Copyright: © Liu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — RRM2 suppression induces cell apoptosis through the Bcl-2/caspase pathway. (A) Knockdown of Bcl-2 in K562G cells. Left panel, PCR band; right panel, the relative band density. (B) Knockdown of RRM2 activated the Bcl-2/Bax and caspase pathways. The levels of Bcl-2, Bax, cleaved-caspase (cas) 3 and 9 were determined by western blot analysis. Upper left panel, western blot band; histograms, the relative band density. t-test, **P<0.01, as compared with the siCT group. RRM2, ribonucleotide reductase regulatory subunit M2.