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RRM2 knockdown suppresses the activation of the Akt pathway. (A) RRM2 knockdown decreased the level of phosphorylated Akt (p-Akt). Upper panel, western blot band; lower histogram, the relative band density. **P<0.01, as compared with the siCT group. NS, not significant. (B) Diagram depicts the role of RRM2 in IR, a novel type of Bcr-Abl-independent resistance in CML. RRM2, ribonucleotide reductase regulatory subunit M2; IR, imatinib-resistant; CML, chronic myeloid leukemia.
