Table IV.
Correlation between CHD1L expression and the clinicopathological features of 80 patients with ICC.
| CHD1L | |||||
|---|---|---|---|---|---|
| Clinicopathological features | No. | High n (%) | Low n (%) | χ2 value | P-value |
| Total cases | 80 | 36 (45.0) | 44 (55.0) | ||
| Sex | 0.522 | 0.47 | |||
| Male | 49 | 23 (46.9) | 26 (53.1) | ||
| Female | 31 | 12 (38.7) | 19 (61.3) | ||
| Age (years) | 1.204 | 0.273 | |||
| ≥55 | 46 | 20 (43.5) | 26 (56.5) | ||
| <55 | 34 | 19 (55.9) | 15 (44.1) | ||
| Histological differentiation | 8.973 | 0.011a | |||
| Well | 23 | 7 (30.4) | 16 (69.6) | ||
| Moderate | 42 | 20 (47.6) | 22 (52.4) | ||
| Poor | 15 | 12 (80.0) | 3 (20) | ||
| Tumor size (cm) | 2.161 | 0.142 | |||
| ≥4.0 | 52 | 33 (63.5) | 19 (36.5) | ||
| <4.0 | 28 | 13 (46.4) | 15 (53.6) | ||
| Vascular invasion | |||||
| Present | 36 | 23 (63.9) | 13 (36.1) | 9.436 | 0.002a |
| Absent | 44 | 13 (29.5) | 31 (70.5) | ||
| CA19-9 (U/ml) | 0.671 | 0.413 | |||
| ≥35 | 45 | 26 (57.8) | 19 (42.2) | ||
| <35 | 35 | 17 (48.6) | 18 (51.4) | ||
| Lymphatic node metastasis | 7.026 | 0.008a | |||
| Present | 48 | 31 (64.6) | 17 (35.4) | ||
| Absent | 32 | 11 (34.4) | 21 (35.6) | ||
| TNM stage (AJCC) | 14.831 | 0.001a | |||
| I–II | 30 | 6 (20.0) | 24 (80.0) | ||
| III | 36 | 19 (52.8) | 17 (47.2) | ||
| IV | 14 | 11 (78.6) | 3 (21.4) | ||
CHD1L, chromodomain helicase/ATPase DNA-binding protein 1-like gene; ICC, intrahepatic cholangiocarcinoma.
a
P<0.05 is significant.