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. 2019 Jun 19;42(2):479–494. doi: 10.3892/or.2019.7205

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Copyright: © Chen et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Matrine exhibits no significant cytotoxic effect to C2C12 myocytes and myotubes. (A) Inhibition rate and (B) IC₁₀ of matrine to C2C12 myocytes for 48 h determined by CCK-8 assay (n=4). (C-F) The mRNA levels of MHC subfamily proteins, including (C) MHC Ib, (D) MHC IIa, (E) MHC IIb and (F) MHC IIx, in myotubes following treatment with matrine (0.025, 0.05, 0.1, 0.2 and 0.4 mM) were analyzed by reverse transcription-quantitative polymerase chain reaction (n=3). Data are presented as the mean ± standard deviation. Statistical significance was determined by one-way ANOVA. **P<0.01, ***P<0.001 vs. untreated control. MHC, myosin heavy chain.