Table 2.
Correlation between chemotherapy response and clinical characteristics in 31 ESCC patients
| Clinicalopathological parameters | Patients (%) | Chemotherapy response (n=31) | P | |
|---|---|---|---|---|
|
| ||||
| PR/CR (n=17) | PD/SD (n=14) | |||
| Age (year) | 0.371 | |||
| ≤60 | 13 (41.9) | 5 | 8 | |
| >60 | 18 (58.1) | 12 | 6 | |
| Gender | 0.476 | |||
| Male | 24 (77.4) | 14 | 10 | |
| Female | 7 (22.6) | 3 | 4 | |
| Smoking | 0.444 | |||
| Yes | 20 (64.5) | 12 | 8 | |
| No | 11 (35.5) | 5 | 6 | |
| Drinking | 0.249 | |||
| Yes | 19 (61.3) | 12 | 7 | |
| No | 12 (38.7) | 5 | 7 | |
| Family history | 0.250 | |||
| Yes | 10 (32.3) | 7 | 3 | |
| No | 21 (67.7) | 10 | 11 | |
| Tumor location | 0.171 | |||
| Upper | 4 (12.9) | 4 | 0 | |
| Middle | 14 (45.2) | 7 | 7 | |
| Lower | 13 (41.9) | 6 | 7 | |
| Tumor size (cm3) | 0.451 | |||
| ≤15.5 | 24 (77.4) | 15 | 9 | |
| >15.5 | 7 (22.3) | 2 | 5 | |
| Tumor differentiation differentiation | 0.555 | |||
| High | 2 (6.5) | 1 | 1 | |
| Middle | 20 (64.5) | 12 | 8 | |
| Low | 9 (29.0) | 4 | 5 | |
| Clinical stage | 0.891 | |||
| II | 7 (22.6) | 4 | 3 | |
| III | 24 (77.4) | 13 | 11 | |
| Pathologic stage | 0.098 | |||
| 0/I/II | 14 (45.2) | 10 | 4 | |
| III/IV | 17 (54.8) | 7 | 10 | |
| T stage | 0.960 | |||
| T1-2 | 11 (35.5) | 6 | 4 | |
| T3-4 | 20 (64.5) | 11 | 10 | |
| N stage | 0.144 | |||
| N0 | 12 (38.7) | 9 | 3 | |
| N1-3 | 19 (61.3) | 8 | 11 | |
| Serum CEA | ||||
| Positive | 2 (6.5) | 1 | 1 | 0.889 |
| Negative | 29 (93.5) | 16 | 13 | |
| Serum SCC | ||||
| Positive | 1 (3.2) | 0 | 1 | 0.270 |
| Negative | 30 (96.8) | 17 | 13 | |
| Protein CDKN1A | 0.024* | |||
| Low | 18 (58.1) | 13 | 5 | |
| High | 13 (41.9) | 4 | 9 | |
| Protein TSPAN4 | 0.002** | |||
| Low | 14 (45.2) | 12 | 2 | |
| High | 17 (54.8) | 5 | 12 | |
| Protein ELAVL2 | 0.005** | |||
| Low | 18 (58.1) | 14 | 4 | |
| High | 13 (41.9) | 3 | 10 | |
| Protein JUNB | 0.473 | |||
| Low | 20 (64.5) | 10 | 10 | |
| High | 11 (35.5) | 7 | 4 | |
| Protein PAAF1 | 0.926 | |||
| Low | 18 (58.1) | 10 | 8 | |
| High | 13 (41.9) | 7 | 6 | |
Note: CEA: Carcinoembryonic antigen; SCCA: Squamous cell carcinoma antigen;
*
P<0.05;
**
P<0.01.