Table 1.
Putative targets of miR-138 in human cancers
| Cancer type | Function | Target |
|---|---|---|
| Glioblastoma (GBM) | Tumor suppressor | EZH2 [32] |
| CDK6 [32] | ||
| E2F2 [32] | ||
| E2F3 [32] | ||
| PD-1 [33] | ||
| CTLA-4 [33] | ||
| Oncogene | C/EBPβ [28] | |
| BIM [34] | ||
| Non-small cell lung cancer (NSCLC) | Tumor suppressor | EGFR [24] |
| SIRT1 [36] | ||
| GIT1 [77] | ||
| SEMA4C [77] | ||
| EZH2 [38] | ||
| PDK1 [78] | ||
| HOXA4 [24] | ||
| SNHG12 [40] | ||
| Oral squamous cell carcinoma (OSCC) | Tumor suppressor | ISG15 [51] |
| ΔNp63 [52] | ||
| YAP1 [49] | ||
| EZH2 [53] | ||
| PD-1 [54] | ||
| CTLA-4 [54] | ||
| Colorectal cancer (CRC) | Tumor suppressor | TERT [59] |
| PD-L1 [58] | ||
| PODXL [60] | ||
| HMGA1 [61] | ||
| TWIST2 [55] | ||
| Lcn2 [57] | ||
| Renal cell cancer (RCC) | Tumor suppressor | EZH2 [69] |
| FOXP4 [70] | ||
| Hepatocellular carcinoma (HCC) | Tumor suppressor | SOX9 [63] |
| Cyclin D3 [62] | ||
| Vimentin [65] | ||
| CCND3 [65] | ||
| Prostate cancer | Tumor suppressor | EZH2 [44] |
| Cervical cancer | Tumor suppressor | SIRT1 [71,72] |
| Gastric cancer | Tumor suppressor | SOX4 [66] |
| HIF-1α [67] |