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. 2019 Jun 1;9(6):1293–1308.

Figure 2.

Figure 2

ATP1B2 knockdown inhibits GBM cells proliferation and cell cycle arrest similar to digoxin. (A-D) 5-Bromo-2’-deoxyuridine (BrdU) or 5-ethynyl-2’-deoxyuridine (EdU) incorporation assay was used to evaluate proliferation rates of ATP1B2 downregulation and digoxin treatment of (A, B) U87 and (C, D) T98G. Quantifications are shown at the right. Data are means ± SD, *, P < 0.05 and ***, P < 0.001. (E-H) Cell cycle analysis of ATP1B2 downregulation and digoxin treatment of (E, F) U87 and (G, H) T98G cells stained with propidium iodide (PI) and DNA content measured using flow cytometry. Quantifications are shown at the right. Data are means ± SD, *, P < 0.05 and ***, P < 0.001.