Table 2.
The influence of PPC on radiation pneumonitis in NSCLC patients
| Patient Characteristics | No. of patients | Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|---|---|
|
|
|
|||||||
| HR | 95% CI | P | HR | 95% CI | P | |||
| Sex | Male | 90 | 1 | 1 | ||||
| Female | 43 | 0.743 | 0.383-1.443 | 0.381 | 0.644 | 0.321-1.291 | 0.215 | |
| Age | < 57 | 68 | 1 | 1 | ||||
| ≥ 57 | 65 | 0.733 | 0.404-1.331 | 0.307 | 0.729 | 0.398-1.337 | 0.307 | |
| Stage | I-II | 22 | 1 | 1 | ||||
| III-IV | 111 | 1.063 | 0.474-2.386 | 0.881 | 1.090 | 0.475-2.504 | 0.839 | |
| Smoking | No | 57 | 1 | 1 | ||||
| Yes | 76 | 1.114 | 0.611-2.033 | 0.724 | 1.374 | 0.728-2.593 | 0.327 | |
| Chemotherapy | No | 14 | 1 | 1 | ||||
| Yes | 119 | 1.706 | 0.528-5.510 | 0.372 | 1.803 | 0.548-5.939 | 0.332 | |
| Radiation Dose | < 5600 | 68 | 1 | 1 | ||||
| ≥ 5600 | 65 | 0.818 | 0.452-1.482 | 0.508 | 0.852 | 0.456-1.592 | 0.616 | |
| MLD | < 15 | 67 | 1 | 1 | ||||
| ≥ 15 | 66 | 2.230 | 1.195-4.161 | 0.012 | 2.374 | 1.266-4.451 | 0.007 | |
| V20 | < 25% | 64 | 1 | 1 | ||||
| ≥ 25% | 69 | 2.334 | 1.237-4.403 | 0.009 | 2.365 | 1.231-4.544 | 0.010 | |
| PPC | No | 46 | 1 | 1 | ||||
| Yes | 87 | 0.551 | 0.304-0.998 | 0.049 | 0.531 | 0.283-0.995 | 0.048 | |
Abbreviations: HR, hazard ratio; CI, confidence interval; MLD, mean lung dose; V20, volume of normal lung receiving ≥ 20 Gy; radiation dose in cGy. Multivariate analyses were adjusted for all factors listed in the table. Either MLD or V20 was used in multivariate analyses.