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. 2019 Jun 28;13:287. doi: 10.3389/fncel.2019.00287

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Copyright © 2019 Costa, Carvalho, Flik, Wilson, Reguenga, Martins and Tavares.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Lentiviral-mediated MOR knockdown at the DRt reduces the analgesic potency of systemic morphine in naïve animals. (A) Withdrawal latencies in the hot-plate test after saline administration followed by incrementing doses of morphine (0.1, 1, 4, and 10 mg/Kg) at 1 week after LV-EGFP or LV-MOR-R injection into the DRt. (B) Cumulative dose response curves of systemic morphine plotted as percentage of maximum possible effect (% MPE) and fitted by non-linear regression. The ED50 of morphine was 5.24 mg/Kg (95% CI: 4.24–6.48 mg/Kg) in the LV-MOR-R group and 2.64 mg/Kg (95% CI 1.97–3.53 mg/Kg) in the LV-EGFP group. Data are presented as mean ± SD (LV-EGFP, n = 6; LV-MOR-R, n = 7).