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. 2019 Jul 3;2:252. doi: 10.1038/s42003-019-0492-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Cp1 in rapid tolerance development. a ST50 values from the first (E1) and second (E2) ethanol exposure when Cp1 is knocked down in all CNS glia. Compared to controls (repo-Gal4/+ and v13959/+), expression of Cp1 RNAi in CNS glia (repo-Gal4/v13959) decreased ST50 values during E1, but not during E2 (two-way ANOVA; genotype, n.s.; ethanol exposure, p < 0.0001; interaction, p = 0.015; *Bonferroni’s multiple comparisons vs. controls for each ethanol exposure, p < 0.05; n = 8). b Development of rapid tolerance (fold change in ST50 from E1 to E2) quantified from the data in a. Expression of Cp1 RNAi in glia (blue bar: repo-Gal4/v13959) increased rapid tolerance development compared to controls (black bars: repo-Gal4/+, v13959/+) (one-way ANOVA, p = 0.0014; *Bonferroni’s multiple comparisons vs. controls, p < 0.05; n = 8). c ST50 values from the first (E1) and second (E2) ethanol exposure when Cp1 is knocked down in cortex glia. Compared to controls (NP2222-Gal4/+ and v13959/+), expression of Cp1 RNAi in cortex glia (NP2222-Gal4/v13959) decreased ST50 during E1, but not during E2 (two-way ANOVA; ethanol exposure, p < 0.0001; genotype, p = 0.0034; interaction, p = 0.0001; *Bonferroni’s multiple comparisons vs. controls for each ethanol exposure, p < 0.05; n = 8). d Development of rapid tolerance (fold change in ST50 from E1 to E2) quantified from the data in c. Expression of Cp1 RNAi in cortex glia (blue bar: NP2222-Gal4/v13959) increased rapid tolerance development compared to controls (black bars: NP2222-Gal4/+, v13959/+) (one-way ANOVA, p = 0.0009; *Bonferroni’s multiple comparisons vs. controls, p < 0.05; n = 8)