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. 2019 Jul 3;10:2936. doi: 10.1038/s41467-019-11003-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — The beneficial metabolic effects displayed by adipo-barr2-KO mice are absent in barr2-PRDM16 double KO mice. a Body weights of control mice (genotype: barr2 f/f Prdm16 f/f) and adipo-barr2-PRDM16 double KO mice (genotype: adipoq-Cre barr2 f/f Prdm16 f/f) maintained on a HFD after 4 weeks of age (n = 6 or 7 per group). b, c Body composition (b) and fat mass (% of body weight) (c) of the indicated mouse strains maintained on a HFD for 15 weeks. d, e IGTT (1 g glucose/kg i.p) (d) and ITT (0.75 U insulin /kg i.p.) (e). Mice were maintained on a HFD for 8–9 weeks (n = 6 or 7 per group). AUC, area under the curve. f, g Freely fed and fasting blood glucose (f) and plasma insulin levels (g) in mice maintained on a HFD for 10 weeks (n = 6 or 7 per group). h Relative transcript levels of browning/beiging marker genes and other key metabolic genes, including barr2, determined by qRT-PCR analysis of iWAT RNA after 16 weeks of HFD feeding (n = 4 per group). Male mice were used for all studies. Data are expressed as means ± s.e.m. *p < 0.05, **p < 0.01 (a two-way ANOVA followed by Bonferroni’s post hoc test; b, c, f–h two-tailed Student’s t-test)