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. 2019 Jul 3;9:9620. doi: 10.1038/s41598-019-46118-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Dynamics of gut bacterial genera between the two community types. (A) Matrix showing the presence or absence of the 50 most discriminating genera detected by partial least squares discriminant analysis (PLS-DA) model. Each entry in the matrix indicates the presence or absence of each genus in each individual. Individuals are grouped by community type. In the heatmap, orange = presence, white = absence; (B) The PLS-DA loading plot shows the contributing bacterial genera towards the separation of the PLS-DA scores between individuals of the community type 1 (green color) and community type 2 (purple color); (C,D) Co-occurrence network of the community type 1 and type 2, respectively. In all cases, the correlations among genera were calculated using the partial correlation and information theory (PCIT) method, which identifies significant co-occurrence patterns. The size of the node is proportional to genera abundance. Node fill color corresponds to phylum taxonomic classification. Edges colors represent positive (red) and negative (blue) connections. The edge thickness is equivalent to the correlation values. Only genera with a relative abundance >0.10 were included.