Table 5.
Univariable analysis of predictors of OS and CSS
| OS | CSS | |||
|---|---|---|---|---|
| Variable | HR (95% CI) | P | HR (95% CI) | P |
| Treatment group | < 0.001 | < 0.001 | ||
| RT | 1 | 1 | ||
| ET | 0.349 (0.279–0.435) | < 0.001 | 0.184 (0.130–0.260) | < 0.001 |
| ES | 0.313 (0.245–0.398) | < 0.001 | 0.237 (0.171–0.328) | < 0.001 |
| Age (years) | ||||
| Early (75–79) | 1 | 1 | ||
| Elderly (> 79) | 1.552 (1.318–1.827) | < 0.001 | 1.708 (1.391–2.098) | < 0.001 |
| Gender | ||||
| Female | 1 | 1 | ||
| Male | 1.145 (0.962–1.364) | 0.127 | 1.320 (1.069–1.631) | 0.01 |
| Race | 0.077 | 0.144 | ||
| White | 1 | 1 | ||
| Black | 1.484 (1.049–2.100) | 0.026 | 1.528 (1.002–2.332) | 0.049 |
| Other/unknown | 0.954 (0.674–1.349) | 0.789 | 1.017 (0.667–1.552) | 0.937 |
| Marital status | ||||
| Married | 1 | 1 | ||
| Single/other | 1.286 (1.095–1.511) | 0.002 | 1.346 (1.103–1.644) | 0.004 |
| Tumor grade | < 0.001 | < 0.001 | ||
| G1/2 (well/moderate) | 1 | 1 | ||
| G3/4 (poor/undifferentiated) | 1.410 (1.176–1.692) | < 0.001 | 1.520 (1.221–1.893) | < 0.001 |
| Unknown | 0.795 (0.643–0.984) | 0.035 | 0.641 (0.482–0.852) | 0.002 |
| Histology | 0.001 | < 0.001 | ||
| Squamous cell carcinoma | 1 | 1 | ||
| Adenocarcinoma | 0.730 (0.615–0.867) | < 0.001 | 0.585 (0.476–0.719) | < 0.001 |
| Unknown | 0.896 (0.610–1.315) | 0.574 | 0.602 (0.354–1.023) | 0.061 |
| T stage | < 0.001 | < 0.001 | ||
| T1a | 1 | 1 | ||
| T1b | 1.444 (1.036–2.011) | 0.03 | 1.422 (0.908–2.229) | 0.124 |
| T1x | 2.056 (1.566–2.697) | < 0.001 | 2.511 (1.744–3.615) | < 0.001 |
| Time period | ||||
| Early (2004–2009) | 1 | 1 | ||
| Late (2010–2014) | 0.774 (0.645–0.929) | 0.006 | 0.769 (0.615–0.962) | 0.021 |
CI, confidence interval; CSS, cancer‐specific survival; ES, esophagectomy; ET, endoscopic therapy; HR, hazard ratio; OS, overall survival; RT, radiotherapy.