Table 6.
Multivariable analysis of predictors of OS and CSS
| OS | CSS | |||
|---|---|---|---|---|
| Variable | HR (95% CI) | P | HR (95% CI) | P |
| Treatment group | < 0.001 | < 0.001 | ||
| RT | 1 | 1 | ||
| ET | 0.371 (0.291–0.473) | < 0.001 | 0.213 (0.147–0.309) | < 0.001 |
| ES | 0.305 (0.227–0.408) | < 0.001 | 0.246 (0.166–0.364) | < 0.001 |
| Age (years) | ||||
| Early (75–79) | 1 | 1 | ||
| Elderly (> 79) | 1.269 (1.072–1.502) | 0.006 | 1.354 (1.095–1.673) | 0.005 |
| Tumor grade | 0.001 | < 0.001 | ||
| G1/2 (well/moderate) | 1 | 1 | ||
| G3/4 (poor/undifferentiated) | 1.295 (1.078–1.555) | 0.006 | 1.378 (1.105–1.718) | 0.004 |
| Unknown | 0.838 (0.671–1.406) | 0.118 | 0.739 (0.552–0.991) | 0.043 |
| T stage | 0.005 | 0.041 | ||
| T1a | 1 | 1 | ||
| T1b | 1.758 (1.251–2.471) | 0.001 | 1.819 (1.144–2.894) | 0.012 |
| T1x | 1.322 (0.993–1.759) | 0.056 | 1.396 (0.953–2.043) | 0.087 |
| Time period | ||||
| Early (2004–2009) | 1 | 1 | ||
| Late (2010–2014) | 0.820 (0.683–0.986) | 0.035 | 0.852 (0.680–1.066) | 0.161 |
| Marital status | ||||
| Single/other | 1 | 1 | ||
| Married | 0.840 (0.713–0.991) | 0.038 | 0.834 (0.671–1.036) | 0.101 |
| Histology | 0.415 | 0.954 | ||
| Squamous cell carcinoma | 1 | 1 | ||
| Adenocarcinoma | 1.113 (0.925–1.339) | 0.255 | 0.984 (0.783–1.237) | 0.89 |
| Unknown | 1.220 (0.821–1.811) | 0.325 | 0.920 (0.536–1.581) | 0.764 |
| Gender | ||||
| Female | * | 1 | ||
| Male | * | 0.992 (0.783–1.258) | 0.95 | |
CI, confidence interval; CSS, cancer‐specific survival; ES, esophagectomy; ET, endoscopic therapy; HR, hazard ratio; OS, overall survival; RT, radiotherapy; *No covariates were included.