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Dose–effect relationship of pregabalin (PGB) on CCI-induced mechanical allodynia at: (A) day 4 (B); day 7; (C) day 14. Pregabalin (30, 50, or 100 mg/10 ml/kg) or vehicle were given twice a day. Values represent the mean ± SEM. Difference from vehicle: *p < 0.05, **p < 0.01, ***p < 0.001, and ## p < 0.01 (100 vs 50 mg/kg). Where not indicated, differences with the vehicle were not statistically significant.
