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. 2019 Jun 27;10:711. doi: 10.3389/fphar.2019.00711

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Copyright © 2019 Fotio, Aboufares El Alaoui, Borruto, Acciarini, Giordano and Ciccocioppo

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of co-administration of an ineffective doses of Noxiall^® (Nox) and of pregabalin (PGB) on CCI-induced mechanical allodynia at: (A) day 4; (B) day 7; (C) day 14. Noxiall^® (PEA 100 mg/10 ml/kg, Myrrh 8.32 mg/10 ml/kg, BCP 1.66 mg/10 ml/kg and Rosmarinus officinalis 2.04 mg/10 ml/kg), pregabalin (30 mg/10 ml/kg) their combination (Nox + PGB) or vehicle (Veh) were given twice a day. Values represent the mean ± SEM. Difference from vehicle: **p < 0.01 and ***p < 0.001. Where not indicated, differences with the vehicle were not statistically significant.