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Effect of oral treatment with Noxiall® (Nox) and GBP on CCI-induced heat hyperalgesia in male CD1 mice. Animals (n = 9/group) were treated twice a day with Noxiall® (PEA 300 mg/10 ml/kg, Myrrh 25 mg/10 ml/kg, BCP 5 mg/10 mL/kg and Rosmarinus officinalis 6.16 mg/10 ml/kg), gabapentin (100 mg/10 mg/kg) or vehicle on mechanical allodynia: (A) at day 4; (B) day 7; and (C) day 14, respectively. Values represent the mean ± SEM. Difference from vehicle (Veh): **p < 0.01 and ***p < 0.001.
