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. 2019 Jun 27;7:150. doi: 10.3389/fbioe.2019.00150

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Copyright © 2019 Joachim, Maguire, Schäfer, Gerlach and Czermak.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Concentration of recombinant protein (c_P) compared among the production scales and during the course of induction. (A) Parity plot of c_P at the 20 and 0.5 L scales (adj. R² = 0.93, with a slope of 1.20). (B) Parity plot of c_P at the 7.5 and 0.5 L scales (adj. R² = 0.98, with a slope of 0.88). (C) Parity plot of c_P at the 7.5 and 20 L scales (adj. R² = 0.99, with a slope of 1.32). Solid black lines show the linear fits and dashed gray lines represent lines of parity. (D) Trend of c_P during induction at the 0.5, 7.5, and 20 L scales.