Table 1.
Comparisons of blood biomarker concentration with effusion biomarker concentrations in dogs with septic peritonitis (SP) and in dogs with non-septic peritonitis (NSA).
| SP | NSA | |||||||
|---|---|---|---|---|---|---|---|---|
| Blood median IQR | Effusion median IQR | P-value | Pcorr | Blood median IQR | Effusion median IQR | P-value | Pcorr | |
| Glucose (mg/dL) | 111 | 20 | 0.0011 | 0.0121 | 101 | 94 | 0.1648 | 1.8128 |
| 81–124 | 20–108 | 79–118 | 78–99 | |||||
| Glucose (mmol/L) | 6.2 | 1.1 | 0.0011 | 0.0121 | 5.6 | 5.2 | 0.1648 | 1.8128 |
| 4.5–6.9 | 1.1–6.0 | 4.4–6.6 | 4.4–5.5 | 0.1648 | 1.8128 | |||
| Lactate (mmol/L) | 2.7 | 7.9 | 0.0066 | 0.0726 | 2.0 | 1.8 | 0.6998 | 7.6978 |
| 1.2–4.2 | 2.7–11.3 | 1.3–2.6 | 1.1–2.8 | |||||
| cfDNA (ng/mL) | 379 | 1085 | 0.0003 | 0.0033 | 410 | 470 | 0.7381 | 8.1191 |
| 316–430 | 493–2723 | 316–629 | 269–1157 | |||||
| Nucleosomes (AU) | 0.35 | 13.1 | 0.0001 | 0.0011 | 0.6 | 2.5 | 0.0289 | 0.1848 |
| 0.2–1.1 | 4.4–25.1 | 0.3–1.8 | 0.3–12.9 | |||||
| NT–proCNP (pmol/L) | 11.9 | 6.2 | 0.2460 | 2.910 | 3.9 | 2.3 | 0.1134 | 1.333 |
| 5.6–42.1 | 1.9–25.7 | 2.3–12.0 | 1.6–10.3 | |||||
| PCT (pg/mL) | 99.6 | 38.4 | 0.0028 | 0.0352 | 93.5 | 98.9 | 0.6226 | 6.8486 |
| 40.3–182.9 | 0.0–119.2 | 54.7–208.1 | 29.7–201.6 | |||||
| CCL2 (pg/mL) | 1274 | 16066 | 0.0001 | 0.0011 | 249 | 683 | 0.0001 | 0.0011 |
| 282–2715 | 2508–96300 | 21–431 | 449–2225 | |||||
| CXCL8 (pg/mL) | 785.4 | 4325.0 | 0.0090 | 0.099 | 550.3 | 129.6 | 0.1901 | 2.0911 |
| 495.6–1857.0 | 21.7–75000.0 | 51.8–1372.0 | 21.7–444.7 | |||||
| IL-10 (pg/mL) | 8.5 | 303.1 | 0.0012 | 0.0132 | 8.5 | 8.5 | 0.0312 | 0.3432 |
| 8.5–106.4 | 147.6–1584.0 | 8.5–8.5 | 8.5–31.9 | |||||
| IL-6 (pg/mL) | 9.9 | 2775.0 | 0.0001 | 0.0011 | 3.7 | 37.9 | 0.0029 | 0.0319 |
| 3.7–1573.0 | 363.5–11495.0 | 3.7–15.9 | 3.7–1918.0 | |||||
| KC-Like (pg/mL) | 164.1 | 1215.0 | 0.0011 | 0.0121 | 20.3 | 456.2 | 0.0001 | 0.0011 |
| 8.0–1137.0 | 37.2–6973.0 | 5.3–71.5 | 62.1–757.0 | |||||
Median and IQR concentrations of measured biomarkers in blood and effusion in patients with SP and NSA, and results of univariate comparisons of biomarker concentrations between fluid types with each group by Wilcoxon matched-pairs signed rank test. Biomarkers significantly different after correction for multiple comparisons (P <0.05) between blood and effusion within SP and NSA groups are indicated in bold typeface. AU, arbitrary unit; CCL2, C-C Motif Chemokine Ligand-2; cfDNA, cell-free DNA; CXCL8, chemokine C-X-C motif ligand 8; IL, interleukin; IQR, interquartile range; KC-Like, keratinocyte chemoattractant-like; NSA, non-septic ascites; NT-proCNP, amino-terminal propeptide of C-type natriuretic peptide; Pcorr, P-value corrected for multiple comparisons; PCT, procalcitonin; SP, septic peritonitis.