Table 2.
Comparisons of blood biomarker concentrations in dogs with septic peritonitis (SP) and non-septic peritonitis (NSA).
| Blood | ||||
|---|---|---|---|---|
| SP median IQR | NSA median IQR | P-value | Pcorr | |
| Glucose (mg/dL) | 111 | 101 | 0.7927 | 8.7197 |
| 81–124 | 79–118 | |||
| Glucose (mmol/L) | 6.2 | 5.6 | 0.7927 | 8.7197 |
| 4.5–6.9 | 4.4–6.6 | |||
| Lactate (mmol/L) | 2.7 | 2.0 | 0.3698 | 4.0678 |
| 1.2–4.2 | 1.3–2.6 | |||
| cfDNA (ng/mL) | 379 | 410 | 0.3953 | 4.3483 |
| 316–430 | 316–629 | |||
| Nucleosomes (AU) | 0.35 | 0.60 | 0.2043 | 2.2473 |
| 0.2–1.1 | 0.3–1.8 | |||
| NT-proCNP (pmol/L) | 11.9 | 3.9 | 0.0399 | 0.4389 |
| 5.6–42.1 | 2.3–12.0 | |||
| PCT (pg/mL) | 99.6 | 93.5 | 0.7299 | 8.0289 |
| 40.3–182.9 | 54.7–208.1 | |||
| CCL2 (pg/mL) | 1274 | 249 | 0.0029 | 0.0319 |
| 282–2715 | 21–431 | |||
| CXCL8 (pg/mL) | 785.4 | 550.3 | 0.188 | 2.068 |
| 495.6–1857.0 | 51.8–1372.0 | |||
| IL-10 (pg/mL) | 8.5 | 8.5 | 0.008 | 0.088 |
| 8.5–106.4 | 8.5–8.5 | |||
| IL-6 (pg/mL) | 9.9 | 3.7 | 0.0680 | 0.748 |
| 3.7–1573.0 | 3.7–15.9 | |||
| KC-Like (pg/mL) | 164.1 | 20.3 | 0.0731 | 0.8041 |
| 8.0–1137.0 | 5.3–71.5 | |||
Median and IQR concentrations of measured biomarkers in blood in patients with SP and NSA, and results of univariate comparisons of biomarker concentrations between groups by Mann-Whitney U-test. Biomarkers identified to be significantly different in blood compared between SP and NSA groups after correction for multiple comparisons (P <0.05) are indicated in bold typeface. AU, arbitrary unit; CCL2, C-C Motif Chemokine Ligand-2; cfDNA, cell-free DNA; CXCL8, chemokine C-X-C motif ligand 8; IL, interleukin; IQR, interquartile range; KC-Like, keratinocyte chemoattractant-like; NSA, non-septic ascites; NT-proCNP, amino-terminal propeptide of C-type natriuretic peptide; Pcorr, P value corrected for multiple comparisons; PCT, procalcitonin; SP, septic peritonitis.